In the evolving landscape of genomic medicine, NGS panels for genetic testing have become a cornerstone for diagnosing a wide spectrum of hereditary disorders. Unlike traditional methods that are focused on one gene at a time, NGS panel tests are now allowing clinicians to analyze multiple genes simultaneously. This is leading to quicker and more accurate diagnosis, especially if you consider the disorders where multiple genes may be involved.
With the rise in inherited conditions such as thalassemia, inherited cancers, and developmental disorders, our team at Uncoded is addressing the gap, particularly in areas like prenatal testing for genetic disorders. We offer clinically validated NGS gene panels for not just early diagnosis, but also better-informed treatment decisions. In this article, we will explore how NGS Panels can help improve genetic disorder detection!
How Uncoded Is Transforming Genetic Testing in India via NGS panels
What if these NGS panel test solutions were accessible, affordable, and tailored to the genetic profile of Indian populations? Well, that is exactly what our team at Uncoded aims at. From NGS gene panel assays made specifically for hereditary conditions to delivering highly sensitive and accurate information, we do it all. Here is how Uncoded is bringing a shift in India’s clinical genomics space:
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NGS Panels for Genetic Testing
This is what sets NGS panels for genetic testing apart from conventional diagnostics:
- NGS gene panels enable massively parallel sequencing, which means we can simultaneously analyze tens to hundreds of genes in a single run. This offers far greater breadth than single-gene tests or cytogenetics, which are only limited to one or a few loci.
- Deep sequencing in NGS panels delivers very high coverage, so there can be hundreds to thousands of read-depth. This further allows for the detection of even low-frequency variants, mosaicism, and minimal residual disease (MRD) that standard techniques often miss!
- Since multiple genes are tested at the same time, NGS panel tests eliminate the need for sequential single-gene assays. Which means that the whole process can speed up and reduce the time to results.
- Also, it is cost-effective! Clearly, when many genes are tested at once, NGS panels will typically yield a higher diagnostic return per cost than running multiple individual tests.
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Uncoded’s Clinical-Grade NGS Panel Tests
Here, we understand that one-size-fits-all doesn’t work in genetic diagnostics. That’s why our NGS panel test offerings are tailored to cover a wide range of specialties. Whether it’s prenatal testing for genetic disorders or screening for adult-onset diseases, each of our NGS gene panels is built to bring clarity. Here are the areas it can help with:
- Hematological oncology panels, especially focused on myeloid neoplasms.
- Prenatal carrier screening and diagnostic panels for inherited conditions
- Inherited cancer gene panels
- Neurogenetics and pediatric rare disease panels
These panels are clinically validated and are processed using high-quality reagents and next-generation instruments. In short, whether it’s a targeted NGS gene panel or a broad panel test, our goal is to make genetic insights accessible, reliable, and clinically meaningful for every patient journey.
- Prenatal Testing for Genetic Disorders
Prenatal care is no longer just about routine scans and checkups — it’s now powered by the precision of NGS gene panel testing! Our tools can give parents and clinicians clearer insights earlier in the pregnancy journey, especially when it comes to genetic disorders. This includes:
- Carrier Screening
Couples who are planning for pregnancy can opt for carrier screening through an NGS panel test that screens for over 200 hereditary conditions. These include thalassemia, Spinal Muscular Atrophy (SMA), and Fragile X syndrome.
- Expanded NIPT
Our NGS panels for genetic testing go a step beyond standard non-invasive prenatal testing (NIPT). So, when early ultrasound findings raise suspicions, the targeted gene panels can help zero in on specific developmental disorders.
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NGS Gene Panels Are the Future of Precision Medicine
As genomic science advances, NGS gene panel testing is quickly becoming a cornerstone of precision medicine. Thanks to the advancements of these panels, they don’t just offer a diagnosis but guide a treatment at a highly personalized level. So, whether it is about choosing the right chemotherapy in cancer care or identifying gene-based therapies for inherited conditions, an NGS panel test can bring more clarity that older testing methods cannot match!
This way, beyond diagnoses, the data from these tests can feed into AI-powered tools, which can then help to classify genetic variants and even contribute to ongoing research. Also, another thanks to reduced costs and faster turnaround times, NGS panels for genetic testing are now accessible even in lower-resource clinical settings. This is no longer a luxury, but a growing standard.
What Are The Clinical Benefits?
- Studies show that targeted NGS panels like those covering 50+ key myeloid genes can detect relevant mutations in over 70% of AML cases. And that is a big step forward compared to the older tests that look at just one gene or broad chromosomal changes.
- Some gene mutations, like FLT3 or IDH1/2, can point doctors toward specific targeted therapies. Others, like NPM1 or TP53, help in understanding how aggressive the disease might be and whether a bone marrow transplant should be considered.
- Our RNA-based panel can also detect low levels of disease, which is down to 2% allele frequency. This can be very useful for keeping a track of Minimal Residual Disease (MRD), and catching up on signs early!
Conclusion
In today’s day and age, NGS panels for genetic testing are not just a technological advance but a clinical necessity. By helping decode the complexities of our DNA, these tests reduce diagnostic delays and guide more accurate, personalized treatment plans. At Uncoded, our NGS gene panel is redefining how precision medicine is delivered in India, especially in prenatal testing for genetic disorders and hematological oncology!
So whether it is identifying carrier status, assessing prenatal risk, or detecting mutations through myeloid-specific tests, we are here to empower clinicians with clear, data-driven insights!