HRR Panel
Comprehensive Homologous Recombination Repair Profiling for Precision Oncology Research
The Uncoded HRR NGS Panel is a comprehensive targeted sequencing solution designed to deliver deep insights into homologous recombination repair (HRR) pathway alterations. Unlike conventional assays limited to BRCA1/2, this panel interrogates 40+ clinically relevant HRR genes, enabling broader detection of genomic alterations associated with cancer development, progression, and therapeutic response.
With high accuracy, broad coverage, and a streamlined library preparation workflow, the Uncoded HRR Panel empowers researchers to move beyond single-gene analysis toward a more holistic precision oncology research approach.
Why HRR Profiling Matters
HRR genes form the cell’s primary DNA double-strand break repair system. Pathogenic alterations in these genes compromise genomic stability, making tumour cells vulnerable to PARP inhibitors and other DNA damage response (DDR) therapies. As PARP inhibitors continue to transform breast and ovarian cancer treatment and expand into other tumour types, comprehensive HRR profiling has become essential for advanced cancer research.
Key Features & Benefits
Comprehensive HRR Coverage
- Covers 47 HRR-related genes with complete CDS regions
- Includes key genes such as BRCA1, BRCA2, PALB2, RAD51C/D, ATM, CHEK2, CDK12, and more
- Enables a detailed view of HRR pathway disruptions in a single assay
Extensive Variant Detection
- Detects SNVs and Indels for targeted germline variant analysis
- High sensitivity with reliable detection at low variant allele frequencies
ow Input, Broad Compatibility
- Requires as little as 50 ng gDNA
- Compatible with blood and FFPE tumour samples
Effortless Library Preparation
- Streamlined, intuitive workflow reduces hands-on time
- Optimized chemistry ensures consistent, high-fidelity libraries
Cost-Optimized & Reliable
- Simplified procedures and optimized reagents reduce overall sequencing costs
- A single, end-to-end solution—from library preparation to data analysis
Integrated Data Analysis
Cloud-Based NGS Interpretation Platform
The Uncoded HRR Panel is supported by a powerful cloud-based data analysis solution that enables:
- Automated variant calling, annotation, and classification
- High-throughput, reproducible analysis
- Fast, scalable interpretation of HRR sequencing data
This integrated approach helps researchers confidently identify key genomic alterations while streamlining bioinformatics workflows
Applications of HRR Panel
- HRR pathway research
- PARP inhibitor and DDR therapy studies
- Cancer genomics and tumour biology research
- Precision oncology and biomarker discovery
| Product | Catalog no. | Samples |
| HRR Panel | 10313 | 24 |
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Frequently Asked Questions
Curious about workflow, accuracy, or compatibility? Find all your answers here
What are the challenges of 16S V3-V4?
How does16S V3-V4 improve compliance?
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What is 16S V3-V4?
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How does16S V3-V4 improve compliance?
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